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Melting
Melting computes, for a nucleic acid duplex, the enthalpy and entropy of the helix-coil transition, and then its melting temperatures. Three types of hybridisation are possible: DNA/DNA, DNA/RNA, and RNA/RNA. The program uses the method of nearest-neighbors. The set of thermodymanic parameters can easily be changed, for instance following an experimental breakthrough. The program is coded in ISO C and can be compiled on any operating system. Some Perl scripts are provided to show how melting can be used as a block to construct more ambitious programs.
Last updated 2 Mar, 2005
About
Leadership
- Nicolas Le Novere - Maintainer
- Nicolas Joly - Contributor
- Catherine Letondal - Contributor
- Nirav Merchant - Contributor
Requirements
- Perl (Use Requirement)
- Perl/tk (Use Requirement)
- Perl (Weak Prerequisite)
- Perl/tk (Weak Prerequisite)
Versions
4.2
4.2 stable released 2002-02-21
- Released: 21 Feb, 2002
- Code Maturity: Stable
- Source Archive: http://www.ebi.ac.uk/~lenov/SOFTWARES/melting4_...
- Licenses: GPLv2orlater
- Interfaces: Command Line, X Window System, Web
User Community and Support
User manual included and available in HTML format from http://www.ebi.ac.uk/~lenov/SOFTWARES/melting/melting.html