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Nearest-neighbor compilation of nucleic acid hybridation

Melting computes, for a nucleic acid duplex, the enthalpy and entropy of the helix-coil transition, and then its melting temperatures. Three types of hybridisation are possible: DNA/DNA, DNA/RNA, and RNA/RNA. The program uses the method of nearest-neighbors. The set of thermodynamic parameters can easily be changed, for instance following an experimental breakthrough.


User manual included and available in HTML format from

Heckert gnu.small.png This is a GNU package:melting


Download version 5.2.0 (stable)
released on 8 August 2014

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LicenseVerified byVerified onNotes
GPLv2orlaterGenium29 January 2017

Leaders and contributors

Nicolas Le Novere Maintainer
Catherine Letondal Contributor
Nicolas Joly Contributor
Nirav Merchant Contributor

Resources and communication

AudienceResource typeURI
Bug Tracking,Developer,
User & DeveloperDownload

Software prerequisites

This entry (in part or in whole) was last reviewed on 22 June 2012.


Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the page “GNU Free Documentation License”.

The copyright and license notices on this page only apply to the text on this page. Any software or copyright-licenses or other similar notices described in this text has its own copyright notice and license, which can usually be found in the distribution or license text itself.