Nearest-neighbor compilation of nucleic acid hybridation.
Melting computes, for a nucleic acid duplex, the enthalpy and entropy of the helix-coil transition, and then its melting temperatures. Three types of hybridisation are possible: DNA/DNA, DNA/RNA, and RNA/RNA. The program uses the method of nearest-neighbors. The set of thermodynamic parameters can easily be changed, for instance following an experimental breakthrough.
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released on 8 August 2014
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29 January 2017
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This entry (in part or in whole) was last reviewed on 6 January 2019.