Difference between revisions of "SPINA"

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|Name=SPINA
 
|Name=SPINA
 
|Short description=Calculator for structure parameters of endocrine feedback loops
 
|Short description=Calculator for structure parameters of endocrine feedback loops
|Full description=SPINA is free software that facilitates calculation of constant structure parameters of endocrine feedback control systems. A first successful implementation applies to evaluation of thyroid function. It allows for calculating the thyroid's maximum secretory capacity (GT or SPINA-GT) and the sum activity of peripheral 5'-deiodinases (GD or SPINA-GD) from levels of TSH, (F)T4 and (F)T3 that have been determined once only (SPINA Thyr).
+
|Full description=SPINA is free software that facilitates the calculation of constant structure parameters of endocrine feedback control systems. A first successful implementation applies to the evaluation of thyroid function. It allows for calculating the thyroid's maximum secretory capacity (GT or SPINA-GT) and the sum activity of peripheral 5'-deiodinases (GD or SPINA-GD) from levels of TSH, (F)T4 and (F)T3 that have been determined once only (SPINA Thyr).
  
This method is increasingly used in experimental research. SPINA Thyr has been evaluated in clinical trials covering more than 10,000 subjects with various disorders of thyroid homeostais. Additional applications targeting other endocrine feedback loops are currently being developed or prepared, respectively.
+
This method is increasingly used in experimental research. SPINA Thyr has been evaluated in clinical trials covering more than 10,000 subjects with various disorders of thyroid homeostasis. Additional applications targeting other endocrine feedback loops are currently being developed or prepared, respectively.
  
 
SPINA Thyr is a free application that calculates GT and GD. Source code is provided for Lazarus and Free Pascal. The program is compatible with most desktop Linux distributions, Mac OS X and Windows.
 
SPINA Thyr is a free application that calculates GT and GD. Source code is provided for Lazarus and Free Pascal. The program is compatible with most desktop Linux distributions, Mac OS X and Windows.
 
|Homepage URL=http://spina.sf.net
 
|Homepage URL=http://spina.sf.net
 +
|Version download=http://spina.sourceforge.net/download.html
 
|Is High Priority Project=No
 
|Is High Priority Project=No
 
|VCS checkout command=svn co svn://svn.code.sf.net/p/spina/code/trunk
 
|VCS checkout command=svn co svn://svn.code.sf.net/p/spina/code/trunk
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|Related projects=SimThyr, Lazarus, Free Pascal
 
|Related projects=SimThyr, Lazarus, Free Pascal
 
|Keywords=SPINA, thyroid, health, science, cybernetics
 
|Keywords=SPINA, thyroid, health, science, cybernetics
|Version identifier=4.0
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|Version identifier=4.1.1
|Version date=2015/01/13
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|Version date=2020/01/25
 
|Version status=stable
 
|Version status=stable
|Version download=http://sourceforge.net/projects/spina/files/
 
 
|Test entry=No
 
|Test entry=No
 
|Last review by=Bendikker
 
|Last review by=Bendikker
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BSD License
 
BSD License
  
Copyright (c) 1994-2015, Dr. Johannes W. Dietrich M.D., Klinikum der Universitaet Muenchen, Universitaetsklinikum Ulm, and Universitaetsklinikum Bergmannsheil, Ruhr-Universitaet Bochum.
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Copyright (c) 1994-2020, PD Dr. med. Johannes W. Dietrich M.D., Klinikum der Universitaet Muenchen, Universitaetsklinikum Ulm, and Universitaetsklinikum Bergmannsheil, Ruhr-Universitaet Bochum.
  
 
All rights reserved.
 
All rights reserved.
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In order to cite SPINA Thyr in publications use:
 
In order to cite SPINA Thyr in publications use:
  
Dietrich, J. W., M. R. Fischer, J. Jauch, E. Pantke, R. Gärtner und C. R. Pickardt (1999). "SPINA-THYR: A novel systems theoretic approach to determine the secretion capacity of the thyroid gland." European Journal of Internal Medicine 10 (Suppl. 1) (May 1999): S34.
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J. W. Dietrich (1994-2020). SPINA Thyr, software for structure parameter inference approach of thyroid function. RRID:SCR_014352. doi: 10.5281/zenodo.3596049. http://spina.medical-cybernetics.de
  
 
Additionally you might want to cite one of the following papers:
 
Additionally you might want to cite one of the following papers:
 +
 +
Dietrich, J. W., M. R. Fischer, J. Jauch, E. Pantke, R. Gärtner und C. R. Pickardt (1999). "SPINA-THYR: A novel systems theoretic approach to determine the secretion capacity of the thyroid gland." European Journal of Internal Medicine 10 (Suppl. 1) (May 1999): S34.
  
 
Dietrich JW, Tesche A, Pickardt CR, Mitzdorf U. Fractal Properties of the Thyrotropic Feedback Control: Implications of a Nonlinear Model Compared with Empirical Data. In: Trappl R, ed. Cybernetics and Systems 2002. Vienna: Austrian Society for Cybernetic Studies; 2002:329-34.
 
Dietrich JW, Tesche A, Pickardt CR, Mitzdorf U. Fractal Properties of the Thyrotropic Feedback Control: Implications of a Nonlinear Model Compared with Empirical Data. In: Trappl R, ed. Cybernetics and Systems 2002. Vienna: Austrian Society for Cybernetic Studies; 2002:329-34.
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Hoermann R, Midgley JE, Giacobino A, Eckl WA, Wahl HG, Dietrich JW, Larisch R (2014). Homeostatic equilibria between free thyroid hormones and pituitary thyrotropin are modulated by various influences including age, body mass index and treatment. Clin Endocrinol (Oxf). 2014 Dec;81(6):907-15. doi: 10.1111/cen.12527. PMID 24953754.
 
Hoermann R, Midgley JE, Giacobino A, Eckl WA, Wahl HG, Dietrich JW, Larisch R (2014). Homeostatic equilibria between free thyroid hormones and pituitary thyrotropin are modulated by various influences including age, body mass index and treatment. Clin Endocrinol (Oxf). 2014 Dec;81(6):907-15. doi: 10.1111/cen.12527. PMID 24953754.
|License verified by=Jwdietr
+
 
Cmhobbs
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Hoermann R, Midgley JE, Larisch R, Dietrich JW. Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects. Horm Metab Res. 2015 Mar 6. PMID 25750078.
|License verified date=2015/01/31
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 +
Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH., Midgley JE, Hoermann R. (2016) Calculated parameters of thyroid homeostasis: Emerging tools for differential diagnosis and clinical research. Frontiers in Endocrinology. 2016; 7:00057. PMID 27375554. doi: 10.3389/fendo.2016.00057.
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Chatzitomaris A, Hoermann R, Midley JE, Hering S, Urban A, Dietrich B, Abood A, Klein HH, Dietrich JW (2017). Thyroid Allostasis ñ Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress and Developmental Programming. Frontiers in Endocrinology. 2017; 8:00163. PMID 28775711. doi: 10.3389/fendo.2017.00163
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 +
Dietrich JW, Midgley JEM, Hoermann R (2018). Homeostasis and Allostasis of Thyroid Function. Frontiers Media SA, Lausanne 2018. ISBN 9782889455706. doi: 10.3389/978-2-88945-570-6
 +
|License verified by=JwdietrCmhobbs
 +
|License verified date=2020-01-25
 +
|License note=https://sourceforge.net/projects/spina/files/license.txt
 +
}}
 +
{{Software category
 +
|Biology=health-and-medicine
 +
|Education=adult
 +
|Interface=x-window-system
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|Programming-language=pascal
 +
|Runs-on=Windows, BSD, OS X
 +
|Science=biology
 +
|Use=education, science
 +
|Version-control=subversion
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|Works-with=barcodes, xml
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}}
 +
{{EntryGNU
 +
|Is GNU=No
 
}}
 
}}
 
{{Person
 
{{Person
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|Resource URL=http://sourceforge.net/p/spina/wiki/Version%20history/
 
|Resource URL=http://sourceforge.net/p/spina/wiki/Version%20history/
 
}}
 
}}
{{Software category
+
{{Resource
|Biology=health-and-medicine
+
|Resource audience=SPINA Thyr
|Education=adult
+
|Resource URL=https://doi.org/10.5281/zenodo.3596049
|Interface=x-window-system
+
}}
|Programming-language=pascal
+
{{Resource
|Runs-on=Windows, BSD, OS X
+
|Resource audience=Manuals and support files
|Science=biology
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|Resource URL=http://spina.sourceforge.net/manual.html
|Use=education, science
+
}}
|Version-control=subversion
+
{{Resource
|Works-with=barcodes, xml
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|Resource kind=Mailing List Info/Archive
 +
|Resource URL=https://lists.ruhr-uni-bochum.de/mailman/listinfo/spina
 +
}}
 +
{{EntryDetails
 +
|Is High Priority Project=No
 +
|VCS checkout command=svn checkout https://svn.code.sf.net/p/spina/code/ spina-code
 +
|Decommissioned or Obsolete=No
 +
|Accepts cryptocurrency donations=No
 +
|Test entry=No
 
}}
 
}}
 
{{Featured}}
 
{{Featured}}

Latest revision as of 13:35, 20 June 2021


[edit]

SPINA

http://spina.sf.net
Calculator for structure parameters of endocrine feedback loops

SPINA is free software that facilitates the calculation of constant structure parameters of endocrine feedback control systems. A first successful implementation applies to the evaluation of thyroid function. It allows for calculating the thyroid's maximum secretory capacity (GT or SPINA-GT) and the sum activity of peripheral 5'-deiodinases (GD or SPINA-GD) from levels of TSH, (F)T4 and (F)T3 that have been determined once only (SPINA Thyr).

This method is increasingly used in experimental research. SPINA Thyr has been evaluated in clinical trials covering more than 10,000 subjects with various disorders of thyroid homeostasis. Additional applications targeting other endocrine feedback loops are currently being developed or prepared, respectively.

SPINA Thyr is a free application that calculates GT and GD. Source code is provided for Lazarus and Free Pascal. The program is compatible with most desktop Linux distributions, Mac OS X and Windows.





Licensing

License

Verified by

Verified on

Notes

Verified by

JwdietrCmhobbs

Verified on

25 January 2020




Leaders and contributors

Contact(s)Role
Roland Gärtner Scientific Advise
Johannes W. Dietrich Initiator and Main Developer
Martin R. Fischer Scientific Advise
Martin Adler Technical Advise
Rudolf Hörmann Scientific Advise
Matthias Holzer Technical Advise
Ulla Mitzdorf Scientific Advise
C. Renate Pickardt Scientific Advise
Phil Hess Technical Advise
John E. Midgley Scientific Advise


Resources and communication

AudienceResource typeURI
SPINA Thyrhttps://doi.org/10.5281/zenodo.3596049
R (Ref)https://cran.r-project.org/web/packages/SPINA
Forumhttp://sourceforge.net/p/spina/discussion
Downloadhttp://sourceforge.net/projects/spina/files
Manuals and support fileshttp://spina.sourceforge.net/manual.html
Changeloghttp://sourceforge.net/p/spina/wiki/Version%20history/
VCS Repository Webviewhttp://sourceforge.net/p/spina/code
Mailing List Info/Archivehttps://lists.ruhr-uni-bochum.de/mailman/listinfo/spina
Homepagehttp://spina.sourceforge.net


Software prerequisites




Entry










"Initiator and Main Developer" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.



"Scientific Advise" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.



"Scientific Advise" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.



"Scientific Advise" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.



"Scientific Advise" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.



"Scientific Advise" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.



"Scientific Advise" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.



"Technical Advise" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.



"Technical Advise" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.



"Technical Advise" is not in the list (Maintainer, Contributor, Developer, Sponsor, Unknown) of allowed values for the "Role" property.


"R (Ref)" is not in the list (General, Help, Bug Tracking, Support, Developer) of allowed values for the "Resource audience" property.












"SPINA Thyr" is not in the list (General, Help, Bug Tracking, Support, Developer) of allowed values for the "Resource audience" property.


"Manuals and support files" is not in the list (General, Help, Bug Tracking, Support, Developer) of allowed values for the "Resource audience" property.





Property "Submitted by" (as page type) with input value "{{{Submitted by}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process. "{{{Submitted date}}}" contains an extrinsic dash or other characters that are invalid for a date interpretation.








Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the page “GNU Free Documentation License”.

The copyright and license notices on this page only apply to the text on this page. Any software or copyright-licenses or other similar notices described in this text has its own copyright notice and license, which can usually be found in the distribution or license text itself.