Calculator for structure parameters of endocrine feedback loops
SPINA is free software that facilitates the calculation of constant structure parameters of endocrine feedback control systems. A first successful implementation applies to the evaluation of thyroid function. It allows for calculating the thyroid's maximum secretory capacity (GT or SPINA-GT) and the sum activity of peripheral 5'-deiodinases (GD or SPINA-GD) from levels of TSH, (F)T4 and (F)T3 that have been determined once only (SPINA Thyr).
This method is increasingly used in experimental research. SPINA Thyr has been evaluated in clinical trials covering more than 10,000 subjects with various disorders of thyroid homeostasis. Additional applications targeting other endocrine feedback loops are currently being developed or prepared, respectively.
SPINA Thyr is a free application that calculates GT and GD. Source code is provided for Lazarus and Free Pascal. The program is compatible with most desktop GNU/Linux distributions, Mac OS X and Windows.
svn checkout https://svn.code.sf.net/p/spina/code/ spina-code
25 January 2020
Leaders and contributors
|Roland Gärtner||Scientific Advise|
|Johannes W. Dietrich||Initiator and Main Developer|
|Martin R. Fischer||Scientific Advise|
|Martin Adler||Technical Advise|
|Rudolf Hörmann||Scientific Advise|
|Matthias Holzer||Technical Advise|
|Ulla Mitzdorf||Scientific Advise|
|C. Renate Pickardt||Scientific Advise|
|Phil Hess||Technical Advise|
|John E. Midgley||Scientific Advise|
Resources and communication
|Manuals and support files||http://spina.sourceforge.net/manual.html|
|VCS Repository Webview||http://sourceforge.net/p/spina/code|
|Mailing List Info/Archive||https://lists.ruhr-uni-bochum.de/mailman/listinfo/spina|
Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the page “GNU Free Documentation License”.
The copyright and license notices on this page only apply to the text on this page. Any software or copyright-licenses or other similar notices described in this text has its own copyright notice and license, which can usually be found in the distribution or license text itself.